Metabolic Effects of Nicotinic Acid and its Derivatives. Influence of food on the bioavailability of drugs. Inter- and intra-subject variation in the first-pass elimination of highly cleared drugs during chronic dosing. Pharmacokinetics and metabolism of antipyrine phenazone after intravenous and oral administration.
It is well known that smoking, charcoal broiled food or cruciferous vegetables induce the metabolism of many xenobiotics, whereas grapefruit juice increases the oral bioavailability of the high clearance drugs nifedipine, nitrendipine or felodipine by inhibiting their presystemic intestinal elimination.
Influence of food on the bioavailability of a sustained-release verapamil preparation. TIPS Jul: Assessment of liver metabolic function: Krishnaswamy K.
World Rev Nutr Diet ; Hyperglycaemia and glucose intolerance produced by diazoxide remit spontaneoudy within h of discontinuing the drug, and can be reversed immediately by treatment with hypoglycaemic sulphonylureas.
Concomitant food intake does enhance the bioavailability and the effect of hydralazine. Increased clearance of propranolol and theophylline by high-protein compared with high-carbohydrate diet.
Under certain circumstances an alcohol-induced stupor or coma may merge insensibly and fatally into a hypoglycaemic coma.
Nutrient effects on drug metabolism and action in the elderly. Carlson, editors]. Pharmacol Ther Effect of food on hepatic blood flow: I have not considered the effects of drugs upon intermediary metabolism, or other carbohydrates of nutritional importance such as fructose, galactose and the disaccharides.
Drug Nutr Interact ; 4: Thus alcohol delays the restoration of blood glucose levels to normal during acute insulininduced hypoglycaemia, even in normal individuals. Printed in Great Britain. The Influence of food on the oral and the intravenous pharmacokinetics of a high clearance drug: The significance of nutrition for the biopharmaceutical characteristics of oral extended release preparations and enteric coated dosage forms.
Certain drugs, especially those which either I displace the sulphonylureas from their binding sites on plasma proteins, e. Stimulation of oxidative drug metabolism by parenteral refeeding of nutritionally depleted patients.
Foods effects on propranolol systemic and oral clearance: Curiously, in acute experiments, both nicotinic acid and Ronicol dramatically lower plasma free fatty acid levels by inhibiting adipose tissue lipolysis, reduce the blood glucose concentration and enhance peripheral glucose uptake.
Reduction of first pass hepatic clearance of propranolol by food. Unlike diazoxide they do not inhibit insulin secretion, which is the main, but not sole, mechanism through which this agent and its analogues exert their hyperglycaemic effect.
Pediatrics ; De Castro, 0. Interactions between environmental chemicals and drug biotransformation in man. Food and nifedipine kinetics.
Extrahepatic metabolism of drugs in humans. Among the environmental factors that may influence drug metabolism, the diet and nutritional status of the individuals are important determinants. FreinkeI, N. Gey and L. Cedarbaum JM. Clin Pharmacokinet ; 8:Among the environmental factors that may influence drug metabolism, the diet and nutritional status of the individuals are important determinants.
As altered drug-metabolising enzyme activities can influence the intensity and duration of drug action, such factors should be considered in pharmacotherapy. For this reason the effects of dietary energy, protein deficiency, nutritional ingredients, special diet forms and Cited by: easily absorbed from the diet, t he metabolism of carbohydrate resolves it It usually occurs when the carbohydrate in the diet is insufficient to meet the demand in the body, with the.
intake. Many of the most widely used ‘drugs’ that affect carbohydrate metabolism are either naturally occurring hormones or analogues of them; others are anutrient or even nutrient constituents of the diet, their effect depending as much upon their quantity and mode of administration as upon their molecular structurc.
I n this brief communication it is proposed to do no more than consider the mode. The diet boosted rapid changes in the composition of the gut microbiota of NAFLD patients, and these low-carbohydrate diet-induced changes were linked to an increased circulation folate.
In addition, the diet increased folate-dependent one-carbon metabolism gene expression in the liver. Effects of an increase in dietary lipid content relative to protein or carbohydrate, and consequences of an alteration in dietary fatty acid composition on oxidative metabolism of drugs in man were npgwebsolutions.com by: 1.
The effect of caffeine ( g/kg diet) on lipid metabolism was examined in rats fed on a stock (low-cholesterol) diet or on a cholesterol plus cholic acid-supplemented (high-cholesterol) semi.